Silverman starred in and produced The Sarah Silverman Program on Comdey Central from 2007 to 2010. She has also had small appearance in many movies including School of Rock, and got leading roles in Wreck-It Ralph and Who's the Caboose?.
She then had a supporting role in Peter Farrelly and Bobby Farrelly’s 1998 comedy smash There’s Something About Mary as a friend of Mary. Silverman on Saturday Night Live as a writer and occasional performer gave a boost in her career. And since then, she has received further exposure on various TV talk shows, television series and movies.
She is in the creative team of JASH that writes and produces the content for the YouTube comedy channel. The JASH channel premiered online March 10, 2013.